Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 6, Issue 3, Pages 268-275Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1573
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Apoptotic cell death is mediated by molecular pathways that culminate in the activation of a family of cysteine proteases, known as the caspases, which orchestrate the dismantling and clearance of the dying cell. However, mounting evidence indicates that a cell that has been treated wit an apoptotic inducer can also initiate a suicide programme that does not rely on caspase activation. Here, we present recent finding sand discuss the physiological relevance of caspase-independent cell death.
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