Journal
APPLIED ORGANOMETALLIC CHEMISTRY
Volume 27, Issue 5, Pages 307-312Publisher
WILEY
DOI: 10.1002/aoc.2977
Keywords
ruthenium complexes; thiosemicarbazones ligand; anticancer research; DFT and TDDFT calculated
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Funding
- National Natural Science Foundation of China [20961001, 21261005, 21203035, 51263002]
- Key Project of Chinese Ministry of Education [2010168]
- Guangxi Natural Science Foundation [2010GXNSFB013014, 2012GXNSFAA053194]
- Scientific Research Fund of Guangxi Provincial Education Department [201106LX273]
- Scientific Research Fund of Guangxi University of Chinese Medicine [2012024]
- Key Laboratory of Beibu Gulf Environment Change and Resources Utilization (Guangxi Teachers Education University), Ministry of Education, China
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A series of half-sandwich ruthenium(II) arene complexes [(6-p-cymene)RuII(R-BzTSC)Cl]Cl (BzTSC=benzaldehyde thiosemicarbazone and R=H, CH3 and C6H5) have been synthesized and characterized by IR, 1H NMR, UV-visible, electrospray ionization mass spectrometry and elemental analysis. The single-crystal structures of and have been determined. The molecular orbitals and electronic absorption spectra of the compounds have been calculated using the DFT and TDDFT methods. The in vitro antiproliferative activities of these complexes have been evaluated against four human cancer cell lines (CNE, H292, SKBR3 and Hey1-B), and is proved to be the most efficient inhibitor, with IC50 values of 20, 31, 10 and 34 m, respectively. Copyright (c) 2013 John Wiley & Sons, Ltd.
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