Journal
INFECTION AND IMMUNITY
Volume 73, Issue 3, Pages 1879-1885Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.3.1879-1885.2005
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Funding
- NIAID NIH HHS [T32 AI060549, U01AI5385802, 1T32AI060549] Funding Source: Medline
- PHS HHS [2T32A8007526] Funding Source: Medline
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We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 It, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.
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