Palladium-catalyzed Suzuki-Miyaura coupling with aryl and heteroaryl bromides using N,N,N′,N′-tetra(diphenylphosphinomethyl)-1,2-ethylenediamine

An easily prepared tetraphosphine N,N,N',N'-tetra(diphenylphosphinomethyl)-1,2-ethylenediamine (1) combined with PdCl2 affords an efficient catalytic system for Suzuki cross-coupling of aryl and heteroaryl bromides. A high turnover number of 750 000 is obtained with the catalyst loading as low as 1?ppm. This catalyst system exhibits good stability and longevity. In this study, a broad scope of substrates is investigated and satisfactory yields are obtained. Copyright (c) 2012 John Wiley & Sons, Ltd.