Journal
APPLIED ORGANOMETALLIC CHEMISTRY
Volume 26, Issue 12, Pages 655-662Publisher
WILEY
DOI: 10.1002/aoc.2928
Keywords
selenium; tellurium; biological activity; anti-cancer activity; metal-based drugs; metals in medicine
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Funding
- Ministry of Higher Education (Malaysia) [UM.C/HIR-MOHE/SC/12]
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An overview highlighting the anti-cancer potential of (bio-essential) selenium- and tellurium-containing species, with an emphasis on biological targets and mechanisms of action, is presented. Studies thus far have focused on selenium(II) compounds (along with to a lesser extent inorganic selenium and selenium nanoparticles) which often successfully exploit the inherent anti-oxidizing ability of selenium. Significantly less work has been conducted in developing anti-cancer tellurium compounds, yet two tellurium(IV) species are proven, clinically, as anti-cancer agents. Given the prevalence of the disease and the accumulated insights into mechanisms of action, the continued development of selenium- and tellurium-containing molecules is an area deserving greater attention. Copyright (C) 2012 John Wiley & Sons, Ltd.
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