Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 13, Issue 5, Pages 1531-1536Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.12.031
Keywords
antibiotics; chromanones; natural product analogues; oxygen heterocycles; pharmacological screening
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A series of novel 2-vinylchroman-4-ones, analogues of the natural products Aposphaerin A and B, were identified as potent antibiotics. Derivatives exhibit a significant activity against multiresistant strains of S. aureus, such as MRSA (methicillin resistant S. aureus). The 2-vinylchroman-4-ones were efficiently prepared by Lewis acid mediated conjugate addition of vinylmagnesium bromide to chromones. (C) 2004 Elsevier Ltd. All rights reserved.
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