Journal
APPLIED ORGANOMETALLIC CHEMISTRY
Volume 23, Issue 4, Pages 150-153Publisher
WILEY
DOI: 10.1002/aoc.1485
Keywords
copper; amination; aryl halides; atmosphere pressure; water
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Funding
- National Natural Science Foundation of China [20402006]
- ECUST
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Direct amination of aryl iodides and bromides with ammonia under 1 atm pressure has been effected using in situ-generated hemilabile coordinated copper(l) species from copper(l) halides or copper metal in aqueous ethylene glycol, producing primary aromatic amines in good yields. Ammonia pressure and water were found to accelerate the copper-mediated reaction while strong chelating ligands showed a suppression effect. A rationale for the copper-mediated amination of aryl halides with ammonia is given based on a double-face role of chelating effect. Copyright (C) 2009 John Wiley & Sons, Ltd.
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