Journal
QUIMICA NOVA
Volume 28, Issue 2, Pages 274-280Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0100-40422005000200019
Keywords
bisphosphonates; bone diseases; high performance liquid chromatography
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BISPHOSPHONATES: SYNTHESIS, CHEMICAL ANALYSIS AND PHARMACOLOGICAL APPLICATIONS. Bisphosphonates are drugs that have been widely used in different bone diseases, and have recently been used successfully against many parasites. Various synthetic routes to prepare different types of bisphosphonates have been described, with distinct potency and pharmacological activity. A number of analytical techniques are currently being used to analyze these drugs; among these, the high performance liquid chromatography (HPLC), with different systems of detection, is worth highlighting. However, the development of more sensitive methods is still necessary, once they are essential for bioavailability and bioequivalence studies. This paper reports the major synthesis routes, chemical analysis methodologies and pharmacological applications of bisphosphonates.
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