Antifungal activity of some Brazilian Hypericum species

Crude methanolic extracts and fractions from the aerial parts of seven species of Hypericum (H. caprifoliatum Chain. and Schltdl., H. carinatum Griseb., H. connatum Lam., H. ternum A. St.-Hil., H. myrianthum Chain. and Schltdl., H. piriai Arechav. and H. polyanthemum Klotzsch ex Reichardt) growing in southern Brazil were analyzed for their in vitro antifungal activity against a panel of standardized and clinical opportunistic pathogenic yeasts and filamentous fungi, including dermatophytes, by the agar dilution method. Chloroform and hexane extracts of H. ternum showed the greatest activity among extracts tested. (c) 2004 Elsevier GmbH. All rights reserved.