Journal
JOURNAL OF COGNITIVE NEUROSCIENCE
Volume 17, Issue 3, Pages 507-517Publisher
MIT PRESS
DOI: 10.1162/0898929053279522
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Funding
- NIMH NIH HHS [MH63901] Funding Source: Medline
- NINDS NIH HHS [NS21135, NS40813] Funding Source: Medline
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Top-down modulation underlies our ability to selectively attend to relevant stimuli and to ignore irrelevant stimuli. Theories addressing neural mechanisms of top-clown modulation are driven by studies that reveal increased magnitude of neural activity in response to directed attention, but are limited by a lack of data reporting modulation Of neural processing speed, as well as comparisons with a perceptual (passive view) baseline necessary to evaluate the presence of enhancement and suppression. Utilizing functional MRI (fMRI) and event-related potential recordings (FRPs), we provide converging evidence that both the magnitude of neural activity and the speed of neural processing are modulated by top-clown influences. Furthermore, both enhancement and suppression Occur relative to a perceptual baseline depending on task instruction. These findings reveal the fine degree of influence that goal-directed attention exerts upon activity within the visual association cortex. We further document capacity limitations in top-down enhancement corresponding with working memory performance deficits.
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