Journal
SPRINGER SEMINARS IN IMMUNOPATHOLOGY
Volume 26, Issue 4, Pages 463-484Publisher
SPRINGER
DOI: 10.1007/s00281-004-0190-2
Keywords
B-1 cell; marginal zone B cell; tolerance; apoptosis; host immunity
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Funding
- NCI NIH HHS [CA104815] Funding Source: Medline
- NIAID NIH HHS [AI46637, AI40305] Funding Source: Medline
- NIAMS NIH HHS [AR47360] Funding Source: Medline
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Marginal zone B cells and B-1 cells have been termed innate-like B cells as they, express limited repertoires that play special roles in immune defenses against common infections. These B cells are the Sources of natural antibodies and are capable of highly accelerated clonal responses that hell) counter blood-borne infections. We have characterized a class of microbial product with highly adapted binding interactions with host immunoglobulins/B cell receptors (BCRs), which enable the targeting of large supra-clonal sets of B cells for activation-associated apoptotic death. In recent studies, we have shown that all B cells with V region -targeted BCRs are Susceptible. However, compared to follicular B cells, in vivo exposure preferentially causes innate-like B cells to undergo induced death with subsequent long-lasting supra-clonal depletion and immune tolerance. Based on these properties, it is likely that B cell superantigens influence the pathogenesis of some common infections, but also may provide novel therapeutic opportunities to treat B cell neoplastic and autoimmune diseases.
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