Journal
SUPPORTIVE CARE IN CANCER
Volume 13, Issue 3, Pages 145-152Publisher
SPRINGER
DOI: 10.1007/s00520-004-0730-2
Keywords
opioids; analgesia; adverse effects; bioavailability; metabolism
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Opioids are the oldest and most effective agents for the short- and long-term control of severe pain, particularly chronic cancer pain palliation. However, morphine and other opioids display wide variations in pharmacological efficacy and tolerability, and a significant number of patients are unable to achieve adequately controlled pain at doses that do not produce intolerable adverse effects. This article reviews factors that affect the efficacy and tolerability of opioid analgesics and clinical strategies for successful pain mangement.
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