4.6 Article

Structural changes to airway smooth muscle in cystic fibrosis

Journal

THORAX
Volume 60, Issue 3, Pages 226-228

Publisher

BMJ PUBLISHING GROUP
DOI: 10.1136/thx.2004.028340

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Funding

  1. NCRR NIH HHS [K23 RR17002, 5 M01 RR-00079] Funding Source: Medline
  2. NHLBI NIH HHS [R01 HL61662] Funding Source: Medline

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Background: Chronic airway obstruction is characteristic of cystic fibrosis (CF) but there are few studies of airway smooth muscle remodelling in CF. Methods: Airway smooth muscle content and mean airway smooth muscle cell size were measured by applying design-based stereology to bronchoscopic biopsy specimens obtained from seven subjects with CF and 15 healthy controls. Results: The smooth muscle content increased by 63% in subjects with CF (mean (SD) 0.173 (0.08) v 0.106 (0.042) mm(3) smooth muscle/mm(3) submucosa, mean difference -0.067; 95% CI -0.12 to -0.013, p = 0.017) but there was no increase in mean cell size (2705 (351) v 2654 (757) mum(3), mean difference 251; 95% CI 2687 to 585, p = 0.87). Conclusions: These findings indicate hyperplasia of airway smooth muscle cells without hypertrophy and suggest that accumulation of airway smooth muscle cells may contribute to airway narrowing and bronchial hyperresponsiveness in CF.

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