Journal
APPLIED OPTICS
Volume 53, Issue 5, Pages 836-840Publisher
OPTICAL SOC AMER
DOI: 10.1364/AO.53.000836
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Funding
- National Nature Science Foundation of China [61036013, 61138003, 61377052]
- Ministry of Science and Technology of China [2009DFA52300]
- Tianjin Municipal Science and Technology Commission [11JCZDJC15200]
- Nature Science Foundation of China [11204141]
- Tianjin Municipal Science
- Technology Commission [12JCYBJC31000]
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In this paper, the phase-stepping technique is applied to improve a phase-sensitive surface plasmon resonance biosensor based on differential interferometry between focused radially polarized and azimuthally polarized cylindrical vector beams. Detailed analysis is presented for the phase-stepping method, and the least squares unwrapping algorithm is employed to detect the phase distribution in correspondence to the refractive index of sample. Benefiting from the phase-stepping technique, both the measurement speed and sensitivity are improved significantly. The proposed sensor maintains high sensitivity of 9.4 x 10(-7) RIU/1 degrees and a wide dynamic range of 0.35 RIU simultaneously. Furthermore, the real-time binding reaction process of bovine serum albumin with antibody is monitored to verify the system for potential biological applications. (C) 2014 Optical Society of America
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