Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 30, Issue 3, Pages 115-118Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2005.01.002
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Funding
- NIGMS NIH HHS [R01 GM062516-04, GM 62516, R01 GM062516, GM 67842, GM 62287] Funding Source: Medline
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SR proteins are essential metazoan splicing factors that contain an RNA-binding domain and an arginine/serine-rich domain that functions to promote assembly of the spliceosome. The prevailing model over the past several years suggests that the RS domains function as protein-interaction domains. However, two new papers from Green et al. demonstrate that these RS domains directly contact the pre-mRNA within the functional spliceosome. The sequential character of these contacts suggests that RS domain interactions with RNA promote spliceosome assembly.
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