Journal
JOURNAL OF CLINICAL GASTROENTEROLOGY
Volume 39, Issue 3, Pages 247-252Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.mcg.0000152746.72149.31
Keywords
hepatocellular carcinoma; radiofrequency catheter ablation; recurrence; surgery; survival
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Goals: To compare the efficacy of radiofrequency ablation (RFA) and surgical resection in a group of patients with a Child-Pugh score of 5 and a single HCC less than 4 cm in diameter. Background: Radiofrequency ablation (RFA) has become a popular method for treatment of hepatocellular carcinoma (HCC) and has been applied as an alternative primary therapy to surgical resection. Study: We compared outcomes for 148 patients treated with RFA (n = 55) and those treated surgically (n = 93). Results: The rate of local recurrence among patients in the RFA group was significantly higher than in the surgery group (P = 0.005), while the incidence of remote recurrence was similar between the two lgroups (P = 0.30). The curnulative 1- and 3-year overall Survival rates (P = 0.24) and the cumulative 1- and 3-year recurrence-free survival rates (P = 0.54) were not significantly different between the two groups. Conclusions: Despite a higher rate of local recurrence, RFA was found to be as effective as surgical resection for the treatment of single small HCC in patients with well-preserved liver function, in terms of the incidence of remote recurrence and the patients' likelihood of achieving overall and/or recurrence-free survival.
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