Journal
MICROBES AND INFECTION
Volume 7, Issue 3, Pages 537-543Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2004.12.011
Keywords
myocarditis; gamma-delta T cells; autoimmunity
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Coxsackieviruses are a cause of clinical myocarditis. Both virus replication and host defense mechanisms, including virus-induced autoimmunity, mediate heart injury and cardiac dysfunction. Vγ 4+ cells kill infected cardiocytes and virus-specific CD4+ Th2 cells through Fas-dependent apoptosis and CD1d. The CD4+ Th1 response is necessary for activation of the autoimmune CD8+ T cells, which kill uninfected cardiocytes through perforin-dependent mechanisms. © 2005 Elsevier SAS. All rights reserved.
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