Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 115, Issue 3, Pages 547-555Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200524405
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Funding
- NHLBI NIH HHS [R01 HL058493, R01-HL58493, P01-HL57278, P01 HL057278] Funding Source: Medline
- NIDDK NIH HHS [R01 DK045416, K01-DK063051, P60 DK020579, P30-DK52574, R01-DK45416, P30 DK052574, K01 DK063051, P60-DK20579] Funding Source: Medline
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The mitochondrion serves a critical role as a platform for energy transduction, signaling, and cell death pathways relevant to common diseases of the myocardium such as heart failure. This review focuses on the molecular regulatory events and downstream effector pathways involved in mitochondrial energy metabolic derangements known to occur during the development of heart failure.
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