Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 15, Issue 5, Pages 1525-1527Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.11.063
Keywords
Lp-PLA2 inhibitor
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A series of (E)-phenyl- and -heteroaryl- substituted O-benzoyl-(or acyl)oximes 3a-n were synthesized for evaluating their human lipoprotein-associated phospholiphase A(2) (Lp-PLA(2)) inhibitory activities. The less lipophilic derivatives 3a-c showed the most potent in vitro inhibitory activity on human Lp-PLA2. (c) 2004 Elsevier Ltd. All rights reserved.
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