Journal
CELL CYCLE
Volume 4, Issue 3, Pages 352-355Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.4.3.1519
Keywords
c-Met; traffic; PKC; endosome; ERK1/2; signals dynamics; focal complexes; integrin; cell migration
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The spatial control of signalling events is critical in determining the outcome of a cellular response. Recent studies on the signal output from the growth factor/ receptor HGF/ c-Met, demonstrates that the PKC-regulated location of downstream transducers, specifically the MAPkinase ERK1/2, has a profound positive influence on cell migration, despite apparently reducing the steady state level of ERK1/2 activation. The mechanisms involved and the implications for signalling studies are discussed.
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