Journal
CLINICAL LYMPHOMA
Volume 5, Issue 4, Pages 285-289Publisher
CIG MEDIA GROUP, LP
DOI: 10.3816/CLM.2005.n.018
Keywords
osteoclast-activating factor; osteoprotegerin; plasma cell dyscrasias; tumor V-H gene
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Immunoglobulin (Ig) M myeloma is a distinct entity with features of multiple myeloma (MM) and Waldenstrom's macroglobulinemia (WM). The malignant cells in IgM myeloma have a distinctive chromosomal translocation that differentiates them from W These cells are postgerminal-center in origin with isotype-switch transcripts. They appear to be arrested at a point of maturation between that of WM and W Preliminary data indicate that a pattern of osteoclast-activating factor and osteoprotegerin expression similar to that observed in classic MM is present in IgM myeloma. Additional studies on patients with this rare tumor may provide further insight into the pathogenesis of bone disease in plasma cell dyscrasias.
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