Journal
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
Volume 16, Issue 2, Pages 153-156Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.1590/S0103-50532005000200005
Keywords
Piper malacophyllum; piperolides; antifungal activity
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [98/05074-0] Funding Source: FAPESP
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Bioactivity- guided fractionation of the CH2Cl2 extract from leaves of Piper malacophyllum using bioautography assay against fungi, led to the isolation of two known bioactive piperolides: 4,6- dimethoxy- 5- E- phenylbutenolide ( 1) and 4,6- dimethoxy- 5- Z- phenylbutenolide ( 2). IR, MS and NMR spectroscopic data were used for the identification of these compounds including comparison with previously reported data. The E configuration is associated to higher activity for compound 1, since the minimum amount required for the growth inhibition of Cladosporium cladosporioides and C. sphaerospermum were 1.0/ 1.0 mu g ( 1) and 5.0/ 10.0 mu g ( 2), respectively.
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