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Stochastic cell

Journal

IUBMB LIFE
Volume 57, Issue 2, Pages 59-63

Publisher

WILEY
DOI: 10.1080/15216540400024314

Keywords

stochasticity; self-organization; gene expression; phase transitions; self-organized criticality; networks biology; nonequilibrium thermodynamics

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Accumulating experimental evidence of stochasticity, self-organization and abrupt non-linear transitions underlying the dynamics of cellular structure and function is increasingly more consistent with the concepts and models of phase transitions, critical phenomena and non-linear thermodynamics rather than with the conventional clockwork description of the cell. The novel emerging image of the stochastic cell suggests that familiar and convenient classico-mechanical interpretations may be limiting our ability to understand the behavior of biological systems and calls for active exploration of alternative interpretational frameworks.

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