Journal
ARCHIVES OF VIROLOGY
Volume 150, Issue 3, Pages 533-556Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-004-0414-8
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L protein of hantaviruses is the RNA transcriptase and replicase that transcribes mRNAs and replicates the genomic RNA using antigenomic RNA as an intermediate. It also appears to have endonuclease activity. In this review, the current knowledge on the hantavirus L protein is presented including sequence motifs conserved in RNA polymerases, mechanisms of RNA synthesis and also the most recent findings on homologous RNA recombination and membrane association.
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