Journal
TRANSFUSION
Volume 45, Issue 3, Pages 295-300Publisher
WILEY
DOI: 10.1111/j.1537-2995.2005.04222.x
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Funding
- NHLBI NIH HHS [R01 HL67384] Funding Source: Medline
- NIDDK NIH HHS [R01 DK53674] Funding Source: Medline
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BACKGROUND: AMD3100, a selective antagonist of CXCR4, rapidly mobilizes CD34+ hematopoietic progenitor cells (HPCs) from marrow to peripheral blood with minimal side effects. STUDY DESIGN AND METHODS: To further investigate potential clinical utility of AMD3100 for CD34+ cell mobilization and collection, a Phase I study in normal volunteers was performed examining single-dose administration of AMD3100 alone and in combination with a standard 5-day granulocyte-colony-stimulating factor (G-CSF) regimen. RESULTS: AMD3100 (160 mu g/kg x 1 on Day 5) significantly increased both G-CSF-stimulated (10 mu g/kg/ day) mobilization of CD34+ cells (3.8-fold) and leukapheresis yield of CD34+ cells. Moreover, collection of CD34+ cells was comparable between individuals mobilized by a single-dose regimen of AMD3100 (240 mu g/ kg) and individuals mobilized with a 5-day regimen of G-CSF AMD3100-mobilized leukapheresis products contained significantly greater numbers of T and B cells compared to G-CSF-stimulated leukapheresis products. CONCLUSION: These findings indicate that AMD3100 can be used alone or as an adjunct to G-CSF to mobilize cells for HPC transplantation.
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