Journal
PLANTA MEDICA
Volume 71, Issue 3, Pages 268-272Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2005-837827
Keywords
Erigeron annus; compositae; eudesmane; sesquiterpenes; anti-tumor activity
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Four new and five known eudesmane-type sesquiterpenes were isolated from the aerial parts of Erigeron annus. The structures of these new compounds were elucidated by spectral means, including 2D-NMR analysis, to be 1 beta,4 beta-dihydroxyeudesman-11-ene; 1 beta,7 alpha-dihydroxyeudesman-4(15)-ene; (1R,5S,6S,7S,10R)-1 beta, 6 alpha-dihydroxyeudesman-4-one and 1 beta-D-glucopyranosyloxy-6 alpha-hydroxyeudesman-4(15)-ene. In addition, a chemical transformation of a known compound 1 beta,6 alpha-dihydroxy-eudesman-4 (15)-ene was carried out and the derivative 1 beta,6 alpha-dihydroxy-4 beta(15)-epoxyeudesmane was obtained. Some of the compounds were evaluated for their in vitro antitumor activities.
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