Journal
AUTOIMMUNITY
Volume 38, Issue 2, Pages 151-153Publisher
INFORMA HEALTHCARE
DOI: 10.1080/08916930500050319
Keywords
autoimmune thyroid diseases; Graves' disease; Hashimoto's thyroiditis; association study
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The etiology of the autoimmune thyroid diseases (AITDs), Graves' disease (GD) and Hashimoto's thyroiditis is largely unknown. However, genetic susceptibility is believed to play a major role. The cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene, encoding a negative regulator of the T-lymphocyte immune response, had been reported to be associated and/or linked to AITD. Recently, AITD susceptibility in the Caucasians was mapped to the 6.1-kb 3'UTR of the CTLA-4 gene, in which the single-nucleotide polymorphism(SNP), CT60, was most strongly associated with AITD. In order to determine the association of the CTLA-4 gene with AITD in the Japanese, case-control association analysis for the CT60 of the CTLA-4 gene using 264 AITD patients and 179 healthy controls was done. The frequency of the disease-susceptible G allele of the CT60 of the Japanese control was higher than that of the Caucasians (72.6 vs. 52.3%). However, the Gallele of the CT60 was associated with GD(84.0 vs. 72.6%, P=0.0008) and AITD(80.1 vs. 72.6%, P=0.009) in the Japanese. Furthermore, the Gallele of the CT60 was associated with the increased risk for GD [P=0.004; odds ratio (OR)=2.0] and AITD (P=0.03; OR=1.6) in a recessive model. These results suggested that the CTLA-4 gene is involved in the susceptibility for GD and AITD in the Japanese.
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