Journal
CANCER
Volume 103, Issue 5, Pages 1092-1095Publisher
WILEY-BLACKWELL
DOI: 10.1002/cncr.20856
Keywords
prostate carcinoma; body mass index; cancer risk; prostate-specific antigen
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Funding
- NCI NIH HHS [U01 CA86402] Funding Source: Medline
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BACKGROUND. Recent studies of men with prostate carcinoma suggest that obesity may be associated with more advanced-stage disease and lower overall Survival rates. One possible link between body mass index (BMI) and prostate carcinoma prognosis may be disease ascertainment. Prostate-specific antigen (PSA) is widely used to screen for prostate carcinoma. METHODS. The authors examined the association between BMI and PSA in a population-based study of 2779 men without prostate carcinoma. Between 2001 and 2004, these men were enrolled in a study sponsored by the San Antonio Center of Biomarkers of Risk, a clinical and epidemiologic center of the Early Detection Research Network of the National Cancer Institute. RESULTS. The mean PSA value decreased in a linear fashion with all increase in BMI category, from 1.01 ng/mL in normal weight men to 0.69 ng/mL in obese (Class III) men, after adjusting for race/ethnicity and age. CONCLUSIONS. Lower levels of PSA in obese and overweight men Could mask biologically consequential prostate carcinoma. (C) 2005 American Cancer Society.
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