Journal
ANNALS OF NEUROLOGY
Volume 57, Issue 3, Pages 439-443Publisher
WILEY
DOI: 10.1002/ana.20387
Keywords
-
Categories
Funding
- NIEHS NIH HHS [R01 ES 10751] Funding Source: Medline
- NINDS NIH HHS [P01 NS 40256, R01 NS 33978] Funding Source: Medline
Ask authors/readers for more resources
To determine whether the microtubule-associated protein tau (MAPT) and a-synuclein (SNCA) genes interact to confer Parkinson's disease (PD) susceptibility, we conducted a study of 557 case-control pairs. There was an increased risk of PD for persons with either SNCA 261/261 or MAPT H1/H1 genotypes as compared with persons with neither (odds ratio, 1.96; 95% confidence interval, 1.34-2.86; p = 0.0003). However, the combined effect of the two genotypes was the same as for either of the genotypes alone (separate and equal). These findings are consistent with in vitro experiments that revealed tau-mediated fibrillization of a-synuclein protein at low concentrations (dose threshold effect).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available