Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 62, Issue 5, Pages 551-577Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-004-4462-3
Keywords
asymmetric cell division; GoLoco motif; G-protein; phospholipase C; RGS proteins
Categories
Funding
- NIGMS NIH HHS [GM062338, GM065533] Funding Source: Medline
- NIMH NIH HHS [F30 MH64319] Funding Source: Medline
Ask authors/readers for more resources
Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs). GPCRs act on inactive Galpha(.)GDP/Gbetagamma heterotrimers to promote GDP release and GTP binding, resulting in liberation of Galpha from Galpha. Galpha(.)GTP and Gbetagamma target effectors including adenylyl cyclases, phospholipases and ion channels. Signaling is terminated by intrinsic GTPase activity of Galpha and heterotrimer reformation - a cycle accelerated by 'regulators of G-protein signaling' (RGS proteins). Recent studies have identified several unconventional G-protein signaling pathways that diverge from this standard model. Whereas phospholipase C (PLC) beta is activated by Galpha and Gbetagamma, novel PLC isoforms are regulated by both heterotrimeric and Ras-superfamily G-proteins. An Arabidopsis protein has been discovered containing both GPCR and RGS domains within the same protein. Most surprisingly, a receptor-independent Galpha nucleotide cycle that regulates cell division has been delineated in both Caenorhabditis elegans and Drosophila melanogaster. Here, we revisit classical heterotrimeric G-protein signaling and explore these new, non-canonical G-protein signaling pathways.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available