Journal
MEDICAL MYCOLOGY
Volume 43, Issue 2, Pages 97-115Publisher
OXFORD UNIV PRESS
DOI: 10.1080/13693780500035979
Keywords
Candida albicans; immunoprevention; prophylaxis; vaccine
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Funding
- NIAID NIH HHS [R01 AI 24912] Funding Source: Medline
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The development of a useful Candida vaccine is a distinct possibility despite the fact that individuals with a lifetime of commensal sensitization do not develop sterile immunity to the organism. An effective Candida vaccine would be invaluable in preventing hematogenously disseminated candidiasis, as well as mucocutaneous disease. This review is a discussion of our current understanding of the interplay between commensal and pathogenic forms of Candida albicans and approaches toward active and passive immunoprevention against candidiasis.
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