Carbon-fluorine two-dimensional NMR correlation spectra

Direct detection heteronuclear correlation (HETCOR) C-13{F-19} and indirect detection gHMQC and gHSQC F-19{C-13} two-dimensional correlation spectra have been compared for 1,3-perfluoro dimethylcyclohexane. Correlations to the geminally non-equivalent fluorine atoms in the CF2 groups are more difficult to unambiguously observe using gHMQC or HETCOR in this typical cyclic fluorochemical in which (2)J(FF) similar to > (1)J(CF), but they are readily observed and assigned in the gHSQC experiment. Excellent 2D gHSQC F-19{C-13} correlation spectra have also been obtained on H(CF2)(4)CH2OH without proton decoupling, although half of the correlations within the several FH multiplets have zero intensity. (c) 2005 Elsevier B.V. All rights reserved.