Journal
GLIA
Volume 49, Issue 4, Pages 467-479Publisher
WILEY
DOI: 10.1002/glia.20132
Keywords
platelet-derived growth factor; neuregulin; extracellular matrix; lipid raft; integrin activation; apoptosis; proliferation; laminin; vitronectin
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Funding
- NINDS NIH HHS [F32-NS11035] Funding Source: Medline
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Central nervous system (CNS) development requires mechanisms for the regulation of cell number. Although growth factors are essential determinants of the proliferation and apoptosis that determine final numbers, the long-range nature of signals from diffusible growth factors makes them insufficient for the provision of the precise and localized signals required. Integration of integrin and growth factor receptor signaling in controlling cell behavior has been an important theme of research over the past several years. The focus of this review is on the mechanisms by which integrin-growth factor interactions regulate the development of oligodendrocytes and provide a mechanism for controlling, both in space and in time, oligodendrocyte numbers in the developing CNS. (C) 2004 Wiley-Liss, Inc.
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