Journal
GENESIS
Volume 41, Issue 3, Pages 133-137Publisher
WILEY
DOI: 10.1002/gene.20099
Keywords
BMP; receptor; gene targeting; Cre-loxP
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Funding
- NHLBI NIH HHS [HL-74352] Funding Source: Medline
- NICHD NIH HHS [HD-35286] Funding Source: Medline
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Bone morphogenetic proteins (BMPs) regulate a wide range of cellular functions that contribute to embryonic development from mesoderm formation to organogenesis. BMP type II receptor (BMPR-II) transduces BMP signals by forming heteromeric complexes with and phosphorylating BMP type I receptors. Heterozygous germline mutations of BMPR-H gene have been identified in patients with familial and sporadic primary pulmonary hypertension, indicating that BMPR-II may contribute to the maintenance of normal pulmonary vascular structure and function. Since embryos homozygous for a null BMPR-U allele died during gastrulation, precluding further studies of BMPR-II function in organ formation and in adult tissues, we generated mice carrying a conditional mutant BMPR-H allele in which exons 4 and 5 were flanked by loxP sequences. We anticipate that studies of mice carrying a floxed BMPR-H allele and a Cre transgene (under the control of a tissue-specific promoter) will enable characterization of the role of BMPR-II in specific cell types during development and in the pathogenesis of cardiovascular diseases. (c) 2005 Wiley-Liss, Inc.
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