Organotin esterification of (E)-3-(3-fluoro-phenyl)-2-(4-chlorophenyl)-2-propenoic acid:: synthesis, spectroscopic characterization and in vitro biological activities.: Crystal structure of [Ph3Sn(OC(O)C(4-ClC6H4)= CH(3-FC6H4))]

Nine organotin esters, Me2SnL2 1, Me3SnL 2, n-Bu2SnL2 3, n-Bu3SnL 4, Ph3SnL 5, (PhCH2)(2)SnL2 6, [(Me2SnL)(2)O](2) 7, Et2SnL2 8 and n-Oct(2)SnL(2) 9, of (E)-3-(3-fluorophenyl)-2-(4-chlorophenyl)-2-propenoic acid, HL have been synthesized and characterized by 13 elemental analysis, IR, Multinuclear NMR (H-1, C-13 and Sn-119) and mass spectrometry. The geometry around the tin atom has been deduced and compared both in solution and solid states. The crystal structure of compound 5 has been determined by X-ray single crystal analysis, which shows a tetrahedral geometry around the tin atom with space group P (1) over bar These compounds have also been screened for bactericidal, fungicidal activities and cytotoxicity data. (c) 2004 Elsevier B.V. All rights reserved.