Journal
NATURE NEUROSCIENCE
Volume 8, Issue 3, Pages 270-272Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1412
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Funding
- Wellcome Trust [087736] Funding Source: Medline
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Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1 have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial working memory (SWM) tasks, although their spatial reference memory remains normal. Here we show that forebrain-localized expression of GFP-tagged GluR-A subunits in GluR-A-deficient mice rescues SWM, paralleling its rescue of CA3-CA1 LTR This provides powerful new evidence linking hippocampal GluR-A-dependent synaptic plasticity to rapid, flexible memory processing.
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