Journal
ANNALS OF NEUROLOGY
Volume 57, Issue 3, Pages 448-452Publisher
WILEY
DOI: 10.1002/ana.20402
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- Alzheimers Research UK [ART-PPG2005A-2] Funding Source: researchfish
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Parkinson's disease patients benefit from deep brain stimulation (DBS) in subthalamic nucleus (STN), but the basis for this effect is still disputed. In this intraoperative microdialysis study, we found elevated cGMP extracellular concentrations in the internal segment of the globus pallidus, despite negligible changes in glutamate levels, during a clinically effective STN-DBS. This supports the view that a clinically beneficial effect of STN-DBS is paralleled by an augmentation (and not an inactivation) of the STN output onto the GPi.
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