Journal
EXPERIMENTAL HEMATOLOGY
Volume 33, Issue 3, Pages 259-271Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.exphem.2004.11.007
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Funding
- NHLBI NIH HHS [R01 HL020899, R01 HL020899-23] Funding Source: Medline
- NIDDK NIH HHS [R01 DK045365, R01 DK045365-06S1] Funding Source: Medline
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Extensive studies during the last 30 years have led to considerable understanding of cellular and molecular control of hemoglobin switching. Cell biology studies in the 1970s defined the control of globin genes during erythroid differentiation and led to development of therapies for sickle cell disease. Molecular investigations of the last 20 years have delineated the two basic mechanisms that control globin gene activity during development-autonomous silencing and gene competition. Studies of hemoglobin switching have provided major insights on the control of gene loci by remote regulatory elements. Research in this field has an impact on understanding regulatory mechanisms in general and is of particular importance for eventual development of molecular cures for sickle cell disease and beta thalassemia. (c) 2005 International Society for Experimental Hematology. Published by Elsevier Inc.
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