Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 53, Issue 3, Pages 735-738Publisher
WILEY
DOI: 10.1002/mrm.20396
Keywords
arterial spin tagging; arterial spin labeling; cerebral blood flow; blood oxygenation level dependant contrast; functional magnetic resonance imaging; physilogical noise
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Attenuating the static signal in arterial spin tagging (ASSIST) was initially developed for 3D imaging of cerebral blood flow. To enable the simultaneous collection of cerebral blood flow and BOLD data, a multi-slice version of ASSIST is proposed. As with the 3D version, this sequence uses multiple inversion pulses during the tagging period to suppress the static signal. To maintain background suppression in all slices, the multi-slice sequence applies additional inversion pulses between slice acquisitions. The utility of the sequence was demonstrated by simultaneously acquiring ASSIST and BOLD data during a functional task and by collecting resting-state ASSIST data over a large number of slices. In addition, the temporal stability of the perfusion signal was found to be 60% greater at 3 T compared to 1.5 T, which was attributed to the insensitivity of ASSIST to physiologic noise.
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