Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 69, Issue 3, Pages 620-622Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.69.620
Keywords
psoralen and ultraviolet-A irradiation (PUVA); cross-linking; oxidative DNA damage; antioxidant
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We examined antioxidants exhibiting no effects on DNA cross-linking, which is the basis of psoralen and ultraviolet-A therapy for skin diseases, and suppressing oxidative DNA damage incidental to the therapy. Epigallocatechin gallate and esculetin effectively suppressed oxidative DNA damage with little effect on the formation of DNA cross-linking. These antioxidants might be useful in suppressing the adverse reaction induced by this therapy.
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