Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 98, Issue 20, Pages 8469-8480Publisher
SPRINGER
DOI: 10.1007/s00253-014-6001-3
Keywords
Synergistic protein; Cellulose hydrolysis; Cellulase; Carbohydrate-binding module; Expansin; Auxiliary Activity family 9; GH61
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Funding
- National Research Foundation of Korea - Korean Government (MSIP) [2013M1A2A2072597]
- Advanced Biomass R&D Center of Korea - Korean Government (MSIP) [2011-0031353]
- National Research Foundation of Korea [2011-0031353, 2013M1A2A2072597] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Reducing the enzyme loadings for enzymatic saccharification of lignocellulose is required for economically feasible production of biofuels and biochemicals. One strategy is addition of small amounts of synergistic proteins to cellulase mixtures. Synergistic proteins increase the activity of cellulase without causing significant hydrolysis of cellulose. Synergistic proteins exert their activity by inducing structural modifications in cellulose. Recently, synergistic proteins from various biological sources, including bacteria, fungi, and plants, were identified based on genomic data, and their synergistic activities were investigated. Currently, an up-to-date overview of several aspects of synergistic proteins, such as their functions, action mechanisms and synergistic activity, are important for future industrial application. In this review, we summarize the current state of research on four synergistic proteins: carbohydrate-binding modules, plant expansins, expansin-like proteins, and Auxiliary Activity family 9 (formerly GH61) proteins. This review provides critical information to aid in promoting research on the development of efficient and industrially feasible synergistic proteins.
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