Journal
IEEE TRANSACTIONS ON NANOBIOSCIENCE
Volume 4, Issue 1, Pages 34-48Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TNB.2004.842463
Keywords
gating currents; ionic currents; S4 segment; voltage sensor
Funding
- NIGMS NIH HHS [GM30376] Funding Source: Medline
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Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the membrane electric field. The movement of the sensor initiates a conformational change in the gate of the conducting pathway thus controlling the flow of ions. Major advances in molecular biology, spectroscopy, and structural techniques are delineating the main features and possible structural changes that account for the function of voltage-dependent channels.
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