Journal
JOURNAL OF PROTEOME RESEARCH
Volume 4, Issue 2, Pages 540-545Publisher
AMER CHEMICAL SOC
DOI: 10.1021/pr0497879
Keywords
matrix implanted laser desorption ionization; mass spectrometry; gold; tissue; ion mobility
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The implantation of low velocity massive gold cluster ions allows homogeneous incorporation of a metallic matrix into the near-surface region of rat brain tissues. Subsequent analysis by laser desorption ionization mass spectrometry yields spectra exhibiting molecular ion peaks in the mass range up to 35 kDa similar to those observed by matrix-assisted LDI. Matrix-implanted LDI when combined with ion-mobility preseparation promises to be a useful technique for molecular imaging of biotissues with a laser microprobe.
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