Journal
JOURNAL OF VIROLOGY
Volume 79, Issue 6, Pages 3873-3877Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.79.6.3873-3877.2005
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Funding
- NIAID NIH HHS [AI53838, T32 AI07520-06, K22 AI053838, T32 AI007520] Funding Source: Medline
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The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-beta) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-beta during HCMW infection. IE86 also efficiently blocked the induction of IFN-beta following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-beta is not limited to HCMW infection, identifying IE2 as an IFN-beta antagonist.
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