Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 72, Issue 3, Pages 320-324Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.2005.72.320
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Funding
- NIAID NIH HHS [N01-AI25489, N01-AI30027] Funding Source: Medline
- ODCDC CDC HHS [U50/CCU620541] Funding Source: Medline
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Adult hamsters that survived experimental West Nile virus (WNV) infection developed persistent viruria. Infectious WNV could be cultured from their urine for up to 52 days. Immunohistochemical examination of kidneys of viruric animals showed foci of WNV antigen in renal tubular epithelial and vascular endothelial cells. These findings are compatible with virus replication and persistent infection of renal epithelial cells. The potential clinical and virologic significance of these findings as well as their possible epidermologic importance are discussed.
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