Journal
GENES & DEVELOPMENT
Volume 19, Issue 5, Pages 517-529Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1284105
Keywords
argonaute; dicer; PTGS; RISC; RNA silencing; RNAi
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Funding
- NIGMS NIH HHS [GM62862-01, GM65236-01] Funding Source: Medline
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RNA silencing pathways convert the sequence information in long RNA, typically double-stranded RNA, into similar to21-nt RNA signaling molecules such as small interfering RNAs (siRNAs) and microRNAs (miRNAs). siRNAs and miRNAs provide specificity to protein effector complexes that repress mRNA transcription or translation, or catalyze mRNA destruction. Here, we review our current understanding of how small RNAs are produced, how they are loaded into protein complexes, and how they repress gene expression.
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