Journal
INFECTION AND IMMUNITY
Volume 73, Issue 3, Pages 1886-1889Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.3.1886-1889.2005
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Funding
- NIAID NIH HHS [R01 AI034436, R01AI34436] Funding Source: Medline
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We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.
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