Rare earth perfluorooctanoate [RE(PFO)3] catalyzed one-pot Mannich reaction:: three component synthesis of β-amino carbonyl compounds

Mannich reaction of acetophenone, aldehydes and aromatic amines catalyzed efficiently by RE(PFO)(3) was described firstly, which carried out smoothly in high yields with three component one-pot method. Furthermore, it was found these catalysts were completely recovered and reused without loss of their catalytic activities and are thus environmentally conscious, and this procedure is a new choice to synthesis beta-aminocarbonyl compounds. (C) 2005 Elsevier B.V. All rights reserved.