Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 97, Issue 19, Pages 8439-8453Publisher
SPRINGER
DOI: 10.1007/s00253-013-5175-4
Keywords
Diketopiperazine; NRPS; CDPS; Biosynthetic gene clusters
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Funding
- 973 program [2013CB734000]
- 863 Program of China [2013AA092902]
- Zhejiang Provincial Natural Science Foundation of China [LQ13B020004]
- Zhejiang Marine Biotechnology Innovation Team [2012R10029-2]
- Ningbo Marine Algae Biotechnology Team [2011B81007]
- K.C. Wong Magna Fund in Ningbo University
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Cyclodipeptides and their derivatives, the diketopiperazines (DKPs), constitute a large class of natural products that exhibit various biological properties. Until recently, there are a few characterized DKP biosynthetic pathways. In all these cases, the formation of the cyclodipeptides that harbor the DKP scaffold is catalyzed either by nonribosomal peptide synthetases or by cyclodipeptide synthases. This review focuses on the DKP biosynthetic pathways and their associated molecular mechanisms.
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