Journal
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
Volume 68, Issue 4, Pages 477-480Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAI.0000000000000501
Keywords
pregnancy; adherence; highly active antiretroviral therapy; South Africa
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Funding
- South African National and Gauteng provincial Department of Health
- Gauteng provincial Department of Health
- US President's Emergency Plan for AIDS Relief (PEPFAR) by USAID [674-A-00-08-00,007-00]
- National Institutes of Health [R00-HD-06-3961]
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Among women who become pregnant after initiating highly active antiretroviral therapy (HAART), few data describe the effect of pregnancy and postpartum on adherence. We conducted a retrospective clinical cohort study among therapy-naive women (age, 18-45 years) initiating HAART in Johannesburg, South Africa. Among 7510 women in our analysis, 896 experienced a pregnancy after starting HAART. Compared with nonpregnant periods of follow-up, there was an increased risk of nonadherence during the postpartum period (weighted risk ratio: 1.46, 95% confidence interval: 1.17 to 1.82) but not during pregnancy itself (weighted risk ratio: 0.95, 95% confidence interval: 0.78 to 1.17).
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